It's amazing like I do. What is a. Yeah. We drink it all the time. Maybe they've like they've definitely like gotten their gotten more on game since then. African-Americans are in the United States. It's really awful. But you do you do sweat out certain compounds like aluminum, aluminum, like it's funny that you can actually excrete certain compounds better from sweat than urine, because that's another way of eliminating things through urine. That means you get more blood flow. And it's funny how, like, you'll get one grey hair and the other grey hairs that cluster around that one, like the clustering. And so it's part of the adaptation process as well, you know, being able to handle the heat stress. It's thought the sars-cov-2 also does it because it goes through the same enters through the same receptor. That's no. It's an awesome place for fitness. I would do I would do my yoga or my ballet and then I would run. They know because they taste it all. I've done it before coming. There you go. As an expert in vitamin D, Rhonda Partick has revealed her most current research regarding the effect of vitamin D including: The aging process I'm not going to take my towel off and jump in the lake. Vitamin Katou usually stays around the periphery, doesn't really go to the liver. That's what I've done in the past. Like, children are really good at that. What kind of a timeline do you think they have for something like this? Someone's talking about cleansing toxins like fuck off. Right. And Trager Day, May 16th. I would love to like do it more. Distilled, aged and bottled by Buffalo Trace Distillery 90 Proof. You go crabbing, you'll find crabs, cycling, exploring rock pools. And unfortunately, coronavirus is one like this has been identified with the sars-cov-2 one virus. And I feel like now for a while during the pandemic, when it started in the lockdown started, people were nicer. (over 2 years), Love our episodes? Totally. So so the problem is, is that calcium can easily form a precipitate in in in general and particularly when phosphorus is around and phosphorus is. And in fact, because the zinc is bound to fight weight, it's less bioavailable. Rhonda Patrick's Comprehensive Joe Rogan Experience Notes Suppose you've enjoyed any of Dr. Patrick's Joe Rogan Experience appearances. So physical activity was like the king. But you know what, I'm talking. I like that for that. You know, there's no data showing that. Living in scotland I could have told you that no sunshine makes you miserable, 6 hours of overcast "daylight" in the winter is pretty brutal. They're not as sore. The other thing that happens is the antibody binds to the virus, doesn't neutralize it, but it like makes this crazy immune complex that, like, activates your immune system to just go haywire and it causes all sorts of pathology. Back in the 60s, there was this antibody dependent enhancement happening. I came on your podcast the first time and we talked about it and then of course, continue to to, you know, publish videos and articles and stuff. And I think people need vitamin D anyways. Yeah. Say it again. She includes a daily dose of 5,000iu each day. Right. And that's the same. Too bad. So so then I found out I was pregnant and so I was like, OK, well, I can't go back to the dentist. Yeah, you can find it, Brian. Month to month and a half or whatever, and we kind of like my team and I just drove in and put together an article, released a podcast on it, a video where we just kind of covered everything. Yeah. He's still suffering from it. So. You'll find it. And I would take these long, deep nose and the whole inside of my nose be like stinging and everything. Bourbon has been designated an essential thing at this time, which I'm all for, that tours at the distillery have been suspended in light of the covid-19 pandemic. It's a lot. Like I said, I just got a sauna. Again, I can't say enough good things about them. I was just happy he was like you, Cortile, if you want, because he has I wouldn't do it. If you would prefer a capsule form of vitamin K2 and vitamin k we suggest . It's in a dark bottle. I've gone places and forgot it in a panic like fuck. The cold shower, sorry, the cold shower. On occasion. Oh, positive. It's a very much like a you know, have someone. Xylitol gum. So what's indicative of their suffering from this vitamin D deficiency. I think we will like there's large there's large scale Serov surveys being done. So we've been doing like. I love it. That's who you would depend upon when you wanted to know. You can't manage that, right? But the whole the thing that I just think that I would like to see more research and I'm just hoping, you know, that that CDC and other people are investigating these these other the cross community. 3. Yeah, I'm just I'm amazed that the numbers of people that are deficient, it's so stunning. Yeah, so that's been done. You know, you're not always you just don't succumb to them. Penetrates into the skin and it's just really good at alleviating soreness. But then as you drop it down, it swings low and it actively decompresses all of your discs. Zinc once a week. In most cases, it will certainly help. I thought rocks were falling from the fucking sky and I couldn't watch the car. So Class Kov one, the virus that was responsible for the original SARS outbreak in 2002 or something, the Mars One in the Middle East. It was so hot like, like, like I, I was, I was like on some kind of mind altering drug like this like and I think that's the point with those guys. Like it's not the same at all as before that was known. BeWellBuzz. But also maybe that is not feeling well because vitamin D deficiency plays a factor in that as well. So it's really exciting because and they're going to do like a dose response where they're going to see how many the Charles Raisen, Dr. Charles Rosen showed one just one single session could result in an antidepressant effect. OK, what am I trying to measure here? Like fuck. And that actually potentially could bind sars-cov-2 virus and prevent it from it's like sequestering it, preventing it from entering the cell. I would take if you just had access to it every day, how often would you take intravenous vitamin C? Oh look. You could bake, you could grill, you could do literally any kind of cooking you want to do. But the whole reason I had one cassana like I like scared to do like I do free weights, I free weights and I'll do that, but like I'm just scared of machines. See, my son's at an age where he's he's not going to really remember. But there's so many people that are just the sky is falling. It doesn't do much for the common cold, but when you take two grams, it can help. You just want to be mean, you know, and that's what a lot of people are doing. #1474 - Dr. Rhonda Patrick The Joe Rogan Experience 125 Clips. I mean, I don't I certainly. You make it from UVB, radiation exposure. Both daily and weekly dosages have shown protective properties. Most zinc is found in in really high in oysters, but not a lot of people. I mean, the blacks, they're basically living in England and Wales are four times more likely to die of covid-19 than than whites when they when they adjusted all that data for socioeconomic status and for other health factors, there were two times more likely to die. I have one friend who he did have had tightness in his chest, but he actually was in outside of like in December. Twenty five minutes on a stationary bike and same things are happening, you know, like blood pressure goes down afterwards, heart rate variability improves, you know, so same things are happening. It's hard. I'm involved a friend of mine, Dr. Eric Gordon, he he's put together. Absolutely mimics it. It is. The Russians like to do that. I get a flare up and it's like I'm sure I'm out. Maybe that's why they're shittier, you know? Yeah, let's definitely talk more. It's for the lung function in the respiratory function. So when when shit goes wrong, they fix it. But we have a terrible recipe, right. And that's what happened with the RSV toddlers. I hope you got some good information on this. And so if you look at these these common cold studies, there's like randomized meta analysis, randomized controlled trials, an analysis of them. You know, like at the time he just thought it was some like a little like whatever that's called chest. Well, you do. Below is an excellent video of Dr. Patrick discussing the benefits of Vitamin D on the Joe Rogan Experience. I know. What is the one I drink. We're going to all like make a trip. There's your immune system. But I love it. So what's so. Two hundred and ten degrees. So this is also a problem with vaccines. That's a giant factor in your immune system. It's a game changer. So you don't worry because I wouldn't be able to talk for like a month. But I think it has huge potential, you know. Outcomes of cancer patients and there's all these studies from the Mayo Clinic came out and they were like, nope, doesn't do that. I monitor that are offering. So it does make sense, but I don't. What if what if, you know, some some common cold coronavirus has gone around and that, you know, those antibodies that they've made to neutralize that coronavirus beta coronavirus are somehow helping with the sars-cov-2 like. Like it's it's a therapeutic treatment more, you know, the IBC where it's been shown to help with like, for example, it's at least in the hospitals in San Diego. Why is it OK? I got some other flavors to the the problem with that is you'll fixate on the one person that says the negative. I'm bringing my son. So people that have blood levels higher than 60 may have just a little bit higher calcium level, but not much. I mean, it's just you could go on and on and on. By that I think so they were. We hear about nurses. In a month they decrease their epigenetic age by two years. Monthly didn't work there. They beat each other with this these branches that are wet. It also causes like kidney problems and all sorts of things. There we go. So that's a marker a month. So that's at least that was the mechanism that was shown with Sajko one. It's really good. They really are when it comes to things like that. It's hard to sleep probably when you're in those. But if you take it like, you know, four times a day, you can stay at 220. I was finding that it was burning my throat and I think I was doing it too often too. I need that to change. I noticed it. It's also the region that that is used to get inside of the cell. Like, why can't you wear a swimsuit? But that's the problem with Twitter, is that you don't see that person. I want the vitamin D thing is so important. So so this is like there's one thing that it's important to keep in mind when we say asymptomatic, like, you know, there's asymptomatic and like a person that never actually gets symptoms. So I have like all the apps and stuff and most of the time like and I turn my my my iPhone screen is like down and they have the black background and all that. That's the thing. Right. So it seems to me the sweet spot you know, and I've been doing it every single day of the quarantine because I have a song in my house. And children are more have a more robust effect than adults. Like, that's the only way to know. Or find out how you can speak to an attorney for advice on the right estate plan. So as opposed to having a severe form, it's just like you're less likely to contract it even more. I love that giant. She typically takes 2 of the Nordic Naturals ProOmega 2000 and 4 of the Nordic Naturals Omega-3 Phospholipids daily. Rhonda has also mentioned she frequently uses the vitamin D brand Life Extension. And so he had us do this thing where, like, everyone had to wake up. Surely people are going to be looking looking at that. So I showed him. So like after the onset of symptoms. CHAVOUS It was a device. Have you had an MRI? I don't I don't have that same perspective. Right. I mean those aren't those are Breece Mark Levine at the NIH. Well, is this I mean, this is decades ago. You're hanging by your ankles and decompressing your spine. And it can lead to a. The infrared scanners are like they're like changing electrons. Podcast Notes is a Signal From the Noise LLC Production, All Right Reserved, Berkshire Hathaway Annual Shareholders Meeting, Christopher Lockhead's Follow Your Different, Everyday Espionage Podcast with Andrew Bustamante, Feel Better, Live More With Dr. Rangan Chatterjee, Moonshots and Mindsets with Peter Diamandis, Network State Podcast with Balaji Srinivasan, Spearhead with Naval Ravikant and Babak Nivi, The Unraveling Podcast with Jocko Willink and Darryl Cooper, This Week in Startups with Jason Calacanis, Where It Happens with Sahil Bloom and Greg Isenberg, Sauna: if you have access use the sauna regularly to improve cardiovascular health and immune functions take a hot bath if you dont have access, Theres a big difference between oral vitamin C and Intravenous vitamin C, You can take vitamin C orally but will need a big dose and it still wont have the same effect; IV once per week if you can, Sleep plays a crucial role in immunity, homeostasis, and regulation of body functions, People are actively working on monoclonal antibodies, Improved therapeutic treatments coming, including more repurposing of drugs that will make things less scary, As you get older your immune system declines, There are lifestyle components of immune system you can be proactive about: exercise, sleep, supplements, nutrition, gut-microbiome health, Besides age, the major regulator of immune function seems to be previous virus exposure, not genetics, At any given point you have antibodies against 10 different viruses but youre not always getting sick, 50-80% of US population has had CMV and most people dont ever know they have had it and show no symptoms, CMV impacts immune function differently depending on when you get it, When youre young, it enhances immune response but for older people its deleterious, Interesting tie-in to COVID-19 because we know older people are more prone to severity, Its likely that theres some cross-immunity happening since SARS-COV-2 viruses is part of beta coronaviruses along with SARS-CoV-1 and MRSA, 15-30% of common colds come from coronaviruses so theres a good hypothesis that potentially one or two of common cold virus antibodies could interact with SARS-CoV-2 and neutralize it, Antibody binds to virus and instead of neutralizing it, changes the configuration so the virus can get into the cell better, This activates the immune system and causes pathology, This results in a higher viral load without antibodies to neutralize, Weve seen it happen with coronaviruses, including SARS-CoV-1 and MRSA, The spike region is where antibodies bind and is also the region the virus uses to get into the cell, Currently seeing two major strain mutations in the spike regions one mutation more prominent in Asia, one mutation more predominant in Europe and North America, Brings to light an interesting genetic link to mutations, Theres a theory that the mutation is causing peoples immune system to become more active and lead to severe COVID-19, Monoclonal antibodies: identify specific antibody that binds to spike protein and manufacture them, Problem is this will offer short lived protection since you are not making your own antibodies as you would with a vaccine, Continuous exploration into repurposing drugs and combination drug treatments, Anecdotally, the majority of people on ventilators die partly because ventilators cause more damage to the lungs and can induce more damage, But its hard to say which came first did the ventilator do the damage or was the damage so severe that the patient needed a ventilator, People with Type O blood seem to be less susceptible to contracting COVID-19, People with Type O blood create Type A antibodies which bind to spike region and neutralize antibody so it cant enter the cell, We saw this in SARS-CoV-1 so maybe same for SARS-CoV-2, Another (unproven) theory: Type O blood people have lower levels of blood factor involved in clotting, Hearing more stories that some prisoners are trying to contract SARS-CoV-2 to get out of jail by spitting in a cup and passing to others, First off, its important to distinguish between asymptomatic and pre-symptomatic, Some people do not have symptoms at the time of testing but develop symptoms later so are actually pre-symptomatic, Its possible that viruses have already gone around that environment so antibodies from those viruses are helping in immunity from SARS-CoV-2, Rhonda was also searching to literature to see whether inmates are vaccinated prior to entering but couldnt find that information, Poor sleep has a huge impact on glucose and spikes and also plays a role in maintaining optimal immune functions, Rhonda takes melatonin to help her sleep, 10 mg/day, Regulating circadian rhythm is crucial for sleep, Rhonda makes sure to have bright light exposure in the morning (e.g., opening curtains, walking outside), and changes the lighting in the house in the evening to red lights, 70% of US population has insufficient Vitamin D levels; 28% are deficient, Body can generate naturally when exposed to sun daily, Obese people in US are also more likely to be vitamin D deficient, Genetic polymorphisms: people that have variations in genes that cause them to have less vitamin D, These people are more likely to die from respiratory infection, African Americans in the US are 28x more deficient in vitamin D than Caucasians, A recent study that looked at COVID-19 patients observed an inverse relationship between vitamin D levels and COVID-19 symptoms: the lower the vitamin D levels, the higher the severity of COVID-19, In Indonesia almost all patients that died from COVID-19 were vitamin D deficient, Melanin blocks ability to produce Vitamin D, In the US and Europe, African Americans and black people are more likely to die from COVID-19, Even when adjusting for SES and lifestyle factors, this was still true so something else must be happening, Tolerable upper intake is 4000 IUs per day but its best to get vitamin D blood test to measure levels, There are clinical studies exploring the role of vitamin D but not many in the US, Rhonda wants to see nurses and first responders take vitamin D to see the role in prevention but those studies are not being done, Joe uses the sauna 7 days/week, 180-degrees for 25 min, Rhonda uses the sauna 5 days/week, 180-degrees for 25 min, Heart rate variability improves, blood pressure goes down, cardiovascular health improves, all-cause mortality decreases, Sauna use also improves immune system and makes you more resilient against infection, Brain-derived neurotropic factors (BDNF) increases with exercise and heat stress (sauna), The positive benefits of physical activity on the cardiovascular system were enhanced when sauna was added, Sauna use increases heat shock proteins which prevent muscle atrophy, neurodegenerative genes, and have anti-depressant effects, People who sat in 160-degree sauna for 30 minutes had a 60% increase in heat shock protein compared to baseline, Large Harvard study being done to assess whether hot yoga increases heat shock protein, Heat shock protein have antiviral activity against influenza A, Regular sauna is heating ambient air which in turn raises core body temperature, Infrared saunas are directly heating body without heating the ambient air for example, in a heating tent or blanket, We know more about the effects of dry sauna, For people who dont have access to sauna, a hot bath is a good modality for heat shock protein, Studies being done to assess whether sauna can have anti-depressant effect on depressed patients, Saunas could also provide an avenue for giving sedentary and disabled people the benefits of physical activity without exercising, Ice baths and cold showers can be comparable to cryotherapy but you have to stay in the cold water longer, Cold shock protein hasnt really been measured in humans, instead whats measured is norepinephrine which has been shown to increase, Cold shock protein and hot shock protein have been shown to improve mood as well, The pharmacokinetics of vitamin C are very different in oral vs IV consumption, Oral vitamin C is good for immune function, etc.